Pre-exposure Prophylaxis Adherence Among Men Who Have Sex With Men: A Systematic Review and Meta-analysis.

OBJECTIVES: The effectiveness and efficiency of pre-exposure prophylaxis (PrEP) in reducing the transmission of human immunodeficiency virus (HIV) among men who have sex with men (MSM) relies on how widely it is adopted and adhered to, particularly among high-risk groups of MSM. The meta-analysis aimed to collect and analyze existing evidence on various factors related to PrEP adherence in MSM, including demographic characteristics, sexual behaviors, substance use, and psychosocial factors. METHODS: The meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search included articles published between January 2018 and December 2022, obtained from the PubMed, ScienceDirect, and Scopus databases. The studies that were included in the analysis reported the proportion of MSM who demonstrated adherence to PrEP and underwent quality appraisal using the Newcastle-Ottawa Scale. RESULTS: Of the 268 studies initially identified, only 12 met the inclusion criteria and were included in the final meta-analysis. The findings indicated that education (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12 to 2.40), number of sexual partners (OR, 1.16; 95% CI, 1.02 to 1.31), engaging in sexual activities with an human immunodeficiency virus-positive partner (OR, 1.59; 95% CI, 1.16 to 2.26), substance use (OR, 0.83; 95% CI, 0.70 to 0.99), and lower levels of depression (OR, 0.55; 95% CI, 0.37 to 0.82) were associated with higher rates of PrEP adherence among MSM. CONCLUSIONS: Despite these findings, further research is necessary to investigate PrEP adherence more comprehensively. The findings of this meta-analysis can be utilized to inform interventions aimed at improving PrEP adherence among MSM and provide directions for future research in this area.

Psychosocial Influences on Coping and Wellbeing during the Covid-19 Lockdown in the Early Days of the Pandemic: A Mixed Methods Research.

This study focuses on the psychosocial impacts of COVID-19 restrictions on wellbeing and uses a mixed methods design to develop a more profound understanding about adaptive coping during stressful situations. The quantitative phase of this study examined the association between psychological capital, perceived stress, coping and wellbeing. The online survey was conducted in May 2020 and had 257 participants. The Structural Equation Modelling (SEM) results showed that the hypothesized model had an adequate fit [χ2(306, N = 257) = 547.185, p = 0.00]; and that both psychological capital and perceived stress were significant predictors of wellbeing. Significantly, young people reported a more negative impact on their wellbeing during the lockdowns. In the subsequent qualitative phase, in-depth interviews with 21 voluntary participants (14 females and 7 males) suggested that individuals could reappraise stressful situations and use coping strategies for psychosocial adaptation. From this research, it was identified that especially the younger age group is at risk, and that that psychosocial resources, such as psychological capital, could be developed to enhance coping and wellbeing with the ongoing impacts of the pandemic.

The relationships between sexual risk behaviors and general health risk behaviors among unmarried youth in Thailand.

OBJECTIVES: The prevalence and correlates of sexual risk behaviors among unmarried youth in Thailand are poorly documented. The objectives of this study were to compare the differences in sexual behaviors across age groups and gender and to identify the relationships between sexual risk behaviors and general health risk behaviors among unmarried Thai youth. METHODS: A population-based, nationally representative, cross-sectional survey was conducted between January and March 2013. The Thai version of the Youth Risk Behavior Survey questionnaire was used to collect data from 800 unmarried Thai youth. RESULTS: Majority of the respondents (65.9%) had not engaged in any sexual risk behavior, 18.7% had engaged in 2-3 sexual risk behaviors, and only 5.5% had engaged in a single sexual risk behavior. Current sexually active youth had higher risk of participating in physical fights (odds ratio = 3.41, 95% confidence interval = 1.53-7.57), smoking cigarette (odds ratio = 4.05, 95% confidence interval = 1.89-8.67), and drinking alcohol (odds ratio = 2.17, 95% confidence interval = 1.08-4.36). CONCLUSION: Thai youth were more likely to be involved in multiple sexual risk behaviors than a single sexual risk behavior. Physical fighting was the strongest general health risk behavior associated with the sexual risk behaviors, followed by substance abuse.